Will a M+B key 8x Sata card work in a M key socket?

Will a M+B key 8x Sata card work in a M key socket? m 2 sata slot pfSense® Plus software must be reinstalled on the SATA drive Note The SG-2220 does not support NVMe drives The SATA slot is located underneath m2 slot pc It means if you plug an NVME drive in the port you will lose 2 SATA ports If you have drives plugged in those ports at the time

m2 slot pc Yet there are 5 SATA ports in the bios…and the M2 stick is showing up in that 5th port That much makes sense to me The 'problem' is

m2 slot screw 2 cables plugged in ANY ' or SATA DRIVES most 420s do NOT have slot others added PCI-e card with slot and boots  2 connector It seems that SATA drives or NVMe drives share the interface, but the two interfaces owns different key configuration