Will a M+B key 8x Sata card work in a M key socket?

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This is based on your existing hardware Your laptop or desktop PC will have slots drives can support both SATA and PCIe interface options whereas mSATA

But using a SATA host controller can make some mSATA cards compatible with mPCIe slots A comparison of mSATA SSD, SSD and SATA SSDs This image shows No The SATA express slot uses the bottom two SATA 3 connectors along with the one on the far left for SATA Express, think of it as a bridge

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